Cholesterol and CHD.

Cardiorespiratory fitness, LDL cholesterol, and CHD mortality in men.

INTRODUCTION There are no published data regarding the joint association of cardiorespiratory fitness (CRF) and LDL cholesterol concentration with subsequent CHD mortality in men. METHODS A total of 40,718 healthy men received a comprehensive baseline clinical examination between 1971 and 2006. CRF was determined from a maximal treadmill exercise test. Participants were divided into categorie...

APOE modulates the correlation between triglycerides, cholesterol, and CHD through pleiotropy, and gene-by-gene interactions.

Relationship loci (rQTL) exist when the correlation between multiple traits varies by genotype. rQTL often occur due to gene-by-gene (G × G) or gene-by-environmental interactions, making them a powerful tool for detecting G × G. Here we present an empirical analysis of apolipoprotein E (APOE) with respect to lipid traits and incident CHD leading to the discovery of loci that interact with APOE ...

Fatty acids and CHD.

During the last century much evidence has accumulated to suggest that from a public health perspective the type of fat is more important than the amount of fat. Saturated and trans-fatty acids increase and both n-6 and n-3 PUFA decrease the risk of CHD. Most of the knowledge about the effects of dietary fatty acids on CHD risk is based on observational studies and controlled dietary experiments...

Risk Factors For CHD

Coronary heart disease (CHD) is the leading cause of death and a significant cause of morbidity among North American women.1 Because CHD typically develops one to two decades later in females than in males, the importance of cardiovascular disease in this group has been overlooked. Studies of CHD treatment have shown a bias against the treatment of women with CHD. A recent survey by the Centers...

SnapShot: Chromatin Remodeling: CHD